IV Ketamine therapy is an interventional psychiatric treatment option used to support individuals with complex and treatment-resistant mental health conditions, including bipolar depression, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), major depressive disorder (MDD), and anxiety disorders.
This treatment is often considered when symptoms persist despite traditional approaches such as antidepressant medications and psychotherapy, or when individuals experience severe or recurrent symptoms that significantly impact daily functioning.
Ketamine is an FDA-approved anesthetic medication that has been used safely in medical settings for decades. When administered in low, carefully monitored doses, IV ketamine may help reduce symptoms more rapidly for some patients by targeting neurochemical pathways different from those affected by standard antidepressants.
At Georgia Behavioral Health, IV ketamine therapy is offered as part of a comprehensive, individualized treatment plan and is only provided after a thorough psychiatric evaluation by a licensed provider to determine clinical appropriateness and safety.
IV ketamine is used off-label for the treatment of depression and other mental health conditions and is not FDA-approved for these indications. Treatment outcomes vary and are not guaranteed.
IV ketamine is administered through an intravenous infusion that delivers a customized dose directly into the bloodstream over approximately 40–60 minutes.
Unlike traditional antidepressants that primarily affect serotonin or norepinephrine and may take weeks to show results, ketamine works on the brain’s glutamate system, which plays a role in mood regulation, neuroplasticity, and stress response. This mechanism may help explain why some patients experience symptom improvement more quickly.
IV ketamine is considered one option within an interventional psychiatry approach, which may also include treatments such as Transcranial Magnetic Stimulation (TMS) or Spravato (esketamine), depending on clinical need.
Treatment plans are individualized. Some patients complete an induction phase followed by tapering or transition to other treatments, such as TMS or medication adjustments, to support longer-term symptom management.
Our clinical staff monitors patients 100% of the time during IV ketamine infusions. While many patients prefer that clinicians are not physically in the room for the entire infusion, patients are continuously observed, and staff are immediately available at all times.
Most patients spend approximately 2 hours per visit, which includes preparation, infusion, and post-treatment monitoring.
Side effects are typically temporary and may occur during or shortly after infusion. These can include:
IV ketamine is not typically covered by insurance, as it is not FDA-approved for the treatment of depression. Our team can discuss payment options and answer questions during your consultation.
Patients are generally advised not to drive on the day of treatment due to possible temporary side effects. Transportation home should be arranged.